https://www.thebakerlab.com/linkpeople daily 0.75 2021-09-01 https://images.squarespace-cdn.com/content/v1/611aa53c933d4a3abde95611/1629228265345-ZEL9N4ZYKLRGE54NZO8O/IMG_8296.jpg LinkPeople https://www.thebakerlab.com/research daily 0.75 2025-12-11 https://images.squarespace-cdn.com/content/v1/611aa53c933d4a3abde95611/1631031894836-8H4T8O4AAGD5Z3EMJKVO/eLifeInsight.png Research - ANP32B, or not to be, that is the question. We put in context several observations made regarding the host proviral ANP32 family member genes. Focusing on the publication from Long et al., we show important amino acid differences that help support influenza virus polymerase activity from these whip-like proteins. https://images.squarespace-cdn.com/content/v1/611aa53c933d4a3abde95611/1631040725602-VE78FBUKGLR4EHXG3EUV/ICC-MS.png Research - Cryptic isoform of MECR antagonizes influenza virus. Viruses commonly exploit essential genes for proviral activities. The metabolic enzyme MECR contains an alternatively spliced isoform that liberates it from the mitochondria to target flu polymerase. This observation may hint at hosts safeguarding antiviral proteins by embedding them within essential genes. https://images.squarespace-cdn.com/content/v1/611aa53c933d4a3abde95611/94e7afc1-c6ff-4d1a-84b8-a1c8e166fc19/Asset+3.png Research - Tandem split-GFP influenza viruses are fit & bright Bulky reporter proteins incorporated into viruses often lead to fitness defects. Our take on the split-GFP approach strings GFP11 molecules together to enhance brightness while minimizing hits to fitness. https://images.squarespace-cdn.com/content/v1/611aa53c933d4a3abde95611/1631033138264-VZ03PY8SIVJP3HFNJTKV/ABreassortant.png Research - Why don’t FLUAV and FLUBV reassort? Reassortment is a major driver of influenza virus diversification where whole genome segments of similar viruses are swapped during coinfection. Though influenza A and B viruses (FLUAV and FLUBV for short) both infect and cause disease in humans, they don’t reassort. We found that viral packaging signal incompatibility cements virus speciation. https://images.squarespace-cdn.com/content/v1/611aa53c933d4a3abde95611/1631032153846-7VG37TMKYSMESQA31H64/ANP32A.png Research - Natural ANP32A splice variants differentially stimulate the flu polymerase. The critical host determinant ANP32A from birds stimulates avian-derived influenza polymerase, but human ANP32A does not. 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